BACKGROUND: Ceftazidime was known to cause
photosensitization reactions. However, how it plays
the role remained unclear. In our study, we aim to
investigate the photosensitization effect of ceftazidime in
erythrocytes via oxidative stress.
METHODS: Samples were divided into six different
groups: negative control group, positive control group
and four experimental groups with 10%, 20%, 30%, and
40% ceftazidime, respectively. The positive control and
experimental groups were exposed to ultraviolet (UV)-light
for 2 hours. Superoxide radical, malondialdehyde (MDA),
carbonyl compounds (CC) and methemoglobin (Met-Hb)
levels were then measured.
RESULTS: The results showed a significant increased of
superoxide radical, MDA, CC and Met-Hb levels in all
experimental groups compared to both negative or positive
control groups (p< 0.05).
CONCLUSION: In conclusion, our study confirmed the
role of ceftazidime as a photosensitizer in erythrocytes via
the oxidative stress mechanisms.
KEYWORDS: ceftazidime, oxidative stress,
photosensitizer, photosensitization.