This study aims to analyze the physical environment of the home in people affected by pulmonary tuberculosis and who are not affected by pulmonary tuberculosis, to determine the effect of the physical condition of housing the physical environment of the home in people affected by pulmonary tuberculosis. The research method used in this study is a survey method. Based on the research, it is known that the influence of the physical condition of housing on patients with pulmonary tuberculosis is that for the lighting variable some of the houses of lung tuberculosis patients are not eligible (89.86%), as well as ventilation (98.6%), humidity (91.3%) and occupancy density meets the requirements (52.2%). Houses with tuberculosis are eligible for variable lighting (10.14%), ventilation (0%), humidity (8.70%) and occupant density (47.8%). Effect of Physical Condition of Housing on Non-Sufferers of Lung Tuberculosis. For lighting variables in the control house (non-pulmonary TB sufferers) that did not meet the requirements (27.54%), ventilation (100%), humidity (57.97%) and occupancy density (18.84%). Whereas in the control house that meets the requirements for lighting (72.46%), ventilation (0.00%), humidity (42.03%), and occupant density (81.16%). Based on the results of this study show that the significance values ??of lighting variables (0.04), humidity (0.004), and occupant density (0.33), which can be concluded that the lighting and humidity variables and occupant density significantly affect the incidence of sufferers (TB) ) in Barito Selatan Regency. As for the control (non-sufferers) of pulmonary tuberculosis, the humidity and occupant density variables have a significant effect. The physical environment of a person with pulmonary tuberculosis on average does not qualify for good lighting, ventilation, humidity and occupant density in the home. While the physical environment that is not sufferers for lighting and density of occupants is more qualified, but for ventilation and humidity is still dominant that does not meet the requirements. There is a real influence on the physical condition of the house from lighting and humidity conditions as well as the density of its inhabitants against patients with pulmonary tuberculosis in Barito Selatan Regency, while the control (non-sufferers) of pulmonary tuberculosis, humidity and occupant density variables have a significant effect after controlling for other research variables.