ABSTRAK

GAMBARAN KADAR KALSIUM TOTAL DAN VITAMIN D PADA ANAK SINDROM NEFROTIK DI RSUD ULIN BANJARMASIN

Nurul Muth Mainnah

Komplikasi pada pasien sindrom nefrotik (SN) adalah hipokalsemia dan defisiensi vitamin D. Hal tersebut disebabkan meningkatnya permeabilitas glomerulus terhadap protein. Penelitian ini bertujuan untuk mengetahui gambaran kadar kalsium total dan vitamin D pada pasien anak SN relaps, SN dependen steroid dan SN resisten steroid (SNRS) di RSUD Ulin Banjarmasin periode Januari 2017-Agustus 2018. Metode penelitian dengan pendekatan cross sectional retrospektif. Didapatkan 21 subjek terdiri dari SN relaps (38,1%), SN dependen steroid (33,3%) dan SNRS (28,6%) dipilih melalui purposive sampling sesuai dengan kriteria inklusi. Hasil penelitian pada anak SN di RSUD Ulin Banjarmasin didapatkan rerata kadar kalsium total 9,35±1,55 mg/dL dan rerata kadar vitamin D 19,85±8,79 ng/mL. Selanjutnya rerata kadar kalsium total pada SN relaps 9,43±1,72 mg/dL, SN dependen steroid 9,46±1,29 mg/dL dan SNRS 9,12±1,83 mg/dL serta rerata kadar vitamin D pada SN relaps 19,56±6,17 ng/mL, SN dependen steroid 21,73±10,46 ng/mL, SNRS 18,03±10,79 ng/mL. Dapat disimpulkan pada anak SN relaps, SN dependen steroid dan SNRS mempunyai rerata kadar kalsium total yang normal dan rerata kadar vitamin D yang menurun.

Kata-kata kunci :  sindrom nefrotik relaps, sindrom nefrotik dependen steroid, sindrom nefrotik resisten steroid, kalsium total,  vitamin D

ABSTRACT

An Overview of The Total Calcium and Vitamin D Levels in Children With Nephrotic Syndrome at Ulin General Hospital Banjarmasin

Nurul Muth Mainnah

Complications nephrotic syndrome (NS) include hypocalcaemia and vitamin D deficiency. That are due to increased glomerular permeability of protein. This study aimed to describe the total calcium and vitamin D levels in children with relapse NS, steroid-dependent NS and steroid-resistant NS (SRNS) at Ulin General Hospital Banjarmasin on January 2017-August 2018. This research method with a retrospective cross-sectional approach. There were 21 subjects consisted of relapse NS (38.1%), steroid dependent NS (33.3%) and SRNS (28.6%) were selected by purposive sampling according to inclusion criteria. The results of the study on NS children at Ulin General Hospital Banjarmasin were found to have a mean total calcium levels of 9.35±1.55 mg/dL and a mean vitamin D levels of 19.85±8.79 ng/mL. Furthermore, the mean total calcium levels in relapse NS was 9.43±1.72 mg/dL, steroid dependent NS 9.46±1.29 mg/dL and SRNS 9.12±1.83 mg/dL and the mean vitamin D levels in relapsed NS 19.56±6.17 ng/mL, steroid-dependent NS 21.73±10.46 ng/mL, SRNS 18.03±10.79 ng/mL. It can be concluded that in children with relapse NS , steroid-dependent NS and SRNS at Ulin General Hospital Banjarmasin have a normal mean total calcium levels and decreased a mean of vitamin D levels.

Keywords:nephrotic syndrome, relapse nephrotic syndrome, steroid-dependent nephrotic syndrome, steroid-resistant nephrotic syndrome, total calcium, vitamin D