Introduction:South Kalimantan, known as the second largest coal supplier in Indonesia, is associated with the presence of significant quantities of coal dust in the environment. Coal dust contains various substances that are carcinogenicand cytotoxic.Direct contactof coal dust to the oral cavity is at risk of gene polymorphism resulting in the manifestationofdiseasesinthemouth.Thestudyaimedtoexplore the relationship between gene polymorphisms affecting oral health conditions and coal dust exposure through a systematic review. Methods: A systematic search of PubMed, Google Scholar, Crossref, Scopus, Web of Science, Lens, and Semantic Scholar databases was conducted for English peer-reviewed articles (1/1/2004–15/9/2024)on oral-related gene polymorphisms from coal dust exposure in humans, animals,andcells.ThereviewfollowedPRISMA2020guidelines,with a narrative synthesis of the findings. Bias was assessed using the Newcastle-OttawaScale(NOS),SYstematicReview Centrefor Laboratory animal Experimentation(SYRCLE) and Quality Assessment Tool for In Vitro Studies (QUIN). Result: Overall 17 studies were included.From all 6.703case-control,136in vivo participantsand60 cell samples showed thatgene polymorphismswere more frequentin the coal dust-exposed group compared to the non-exposed group andthe healthygroup. Predisposing factors such smoking, lengthof time, andagecontributetotriggeringoralgenepolymorphisms.The limitation of this research was the limited number of studies discussing gene polymorphismsdue tocoal dustexposuredirectlyto the oral cavity, which affected the representativeness of the articles.Conclusion: There are polymorphisms in 11 oral-related genes (AhR, CYP1A1,GSTM1,GSTT1,hOGG1,IL6,IL1B,NQO1,TNF,TP53,and XRCC1) after coal dust exposure, presenting genotoxic and mutagenic potential.